Collect elements of the periodic table to form common compounds such as water, salt, sugar, rust, sand, and more. Learn the makeup of atoms that form the sun or metals such as cast iron. And take advantage of the Helium Effect bonus if you remember to talk in a high pitch when you play the helium Keeper! This basic introduction to chemistry requires no previous knowledge to play. For 2-6 players, ages 8 and up. Game Play It all begins with one basic rule: Draw one card, Play one card. You start with a hand of three cards.. add the card you drew to your hand, and then choose one card to play, following the directions written on your chosen card. As cards are drawn and played from the deck, the rules of the game change from how many cards are drawn, played or even how many cards you can hold at the end of your turn.